Noninferiority of biocompatible solutions in peritoneal dialysis cannot be maintained

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Biocompatible Solutions for Peritoneal Dialysis

In 1978, a simplified technique for peritoneal dialysis (PD) using plastic bags and glucose as osmotic agent allowed PD to become accepted as a home-based renal replacement therapy. However, PD was marred by complications including peritonitis and loss of function of the peritoneal membrane. Both complications may be favored by the bioincompatibility of PD solutions. The composition of PD solut...

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Biocompatible peritoneal dialysis solutions: do they indeed affect the outcome?

Numerous studies have confirmed beneficial effects of polyglucose dialysis solution (PG-DS), an amino acid dialysis solution (AA-DS), and bicarbonate (bic) or bicarbonate/lactate (bic/lac) buffered solutions on selected components of peritoneal bioavailability or clinical parameters of peritoneal dialysis (PD) patients. Few adverse effects have also been described. A question arises whether the...

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Biocompatible Peritoneal Dialysis Fluids: Clinical Outcomes

Peritoneal dialysis (PD) is a preferred home dialysis modality and has a number of added advantages including improved initial patient survival and cost effectiveness over haemodialysis. Despite these benefits, uptake of PD remains relatively low, especially in developed countries. Wider implementation of PD is compromised by higher technique failure from infections (e.g., PD peritonitis) and u...

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Peritoneal Dialysis Solutions

Staphylococcus epidermidis is the most frequent cause of peritonitis complicating continuous ambulatory peritoneal dialysis. We studied factors that might influence the growth of S. epidermidis in commercially available peritoneal dialysis solution (PDS). Test strains were inoculated into PDS and incubated overnight at 37°C. Samples were removed at appropriate intervals, bacterial counts were p...

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Association of biocompatible peritoneal dialysis solutions with peritonitis risk, treatment, and outcomes.

BACKGROUND AND OBJECTIVES The effect of biocompatible peritoneal dialysis (PD) solutions on PD-related peritonitis is unclear. This study sought to evaluate the relationship between use of biocompatible solutions and the probability of occurrence or clinical outcomes of peritonitis. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS The study included all incident Australian patients receiving PD ...

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ژورنال

عنوان ژورنال: Kidney International

سال: 2008

ISSN: 0085-2538

DOI: 10.1038/ki.2008.362